In a flashback, Lori Grimes (Sarah Wayne Callies) is talking with other mothers about a fight she had with her husband, Rick Grimes (Andrew Lincoln). Rick's partner, Shane Walsh (Jon Bernthal), pulls up in a police cruiser and tells Lori that Rick has been severely wounded in a highway shootout. Lori then tells her son Carl (Chandler Riggs) the news.
In the present, Carl has been accidentally shot by a man named Otis (Pruitt Taylor Vince), who was hunting for deer. Otis brings Rick, Carl and Shane to a veterinarian named Hershel Greene (Scott Wilson), for whom Otis works as a ranch hand. Hershel lives with his daughters Maggie (Lauren Cohan) and Beth (Emily Kinney), Beth's boyfriend Jimmy (James Allen McCune), and Otis' wife Patricia (Jane McNeill). He treats Carl, but he reveals that the bullet was broken into six fragments. Rick must donate blood to Carl in order to keep him alive.
Lori, Glenn (Steven Yeun), Carol Peletier (Melissa McBride), Daryl Dixon (Norman Reedus) and Andrea (Laurie Holden) are still searching for Carol's daughter Sophia (Madison Lintz), when they overhear a gunshot. Meanwhile, on the highway, Dale Horvath (Jeffrey DeMunn) believes that T-Dog (IronE Singleton) has contracted a blood infection from a wound he received in the previous episode, and both search for antibiotics, but they fail to find any.
At the Greene home, Hershel reveals that Carl needs major surgery to live, and that he will need a respirator. Otis suggests that they might find supplies at a nearby high school – where the Federal Emergency Management Agency has set up a trailer – although the place is likely overrun with walkers. Otis and Shane decide to get the supplies, while Maggie retrieves Lori from the group and brings her to the Greene home. Rick and Hershel discuss the walker epidemic; Rick believes there is no cure, while Hershel has faith that there could be one.
The group searching for Sophia returns to the highway, where Daryl reveals that he has a bag containing painkillers and doxycycline antibiotics that T-Dog can take. Shane and Otis retrieve the supplies, but are spotted by walkers. The two have no choice but to barricade themselves in the high school.
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